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Pathophysiological Aspects of Proteases

9789811061400

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Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases.

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Publisher Springer
Author(s) Sajal Chakraborti, Naranjan S. Dhalla
ISBN-13 9789811061400
Publication date November 2017
Edition 1st
Pages 671
Cover Hardback
This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
 
Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

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Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases

Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases.

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